Methyl isonipecotate → HCID 58504921, compound

HRID 537416Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH:10]([NH:14][S:15]([C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2)(=[O:17])=[O:16])[C:11]([OH:13])=O.[NH:27]1[CH2:32][CH2:31][CH:30]([C:33]([O:35][CH3:36])=[O:34])[CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH:10]([NH:14][S:15]([C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2)(=[O:16])=[O:17])[C:11]([N:27]1[CH2:32][CH2:31][CH:30]([C:33]([O:35][CH3:36])=[O:34])[CH2:29][CH2:28]1)=[O:13]

Participants

Reactant 2

HCID 424914Methyl isonipecotate

HCID 66997948HCID 66997948, compound

Product 1

HCID 58504921HCID 58504921, compound

Procedure

methyl 1-{4-(2-chlorophenyl)-2-[(1H-indol-4-ylsulfonyl)amino]butanoyl}piperidine-4-carboxylate is prepared from 4-(2-chlorophenyl)-2-[(1H-indol-4-ylsulfonyl)amino]butanoic acid and methyl piperidine-4-carboxylate in same manner Example 106 is synthesized. ESI MS Calc. 517.1; Found: 518.5 (M+H)+.

Workup

customis synthesized

Sources & evidence

ORD record: ord-335f8476b9684b4bbf5be843d0feae7b
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859814B2

Reaction notes

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