HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-(((tert-butoxy)carbonyl)amino)-4-phenylbutanoic acid → 4-amino-3,5-dichloro-N-{(1S)-1-[(cis)-octahydroisoquinolin-2(1H)-ylcarbonyl]-3-phenylpropyl}benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-(((tert-butoxy)carbonyl)amino)-4-phenylbutanoic acid | HCID 7018726 | — |
| Reactant | cis-Decahydroisoquinoline | HCID 11062467 | — |
| Reactant | 4-Amino-3,5-dichlorobenzene-1-sulfonyl chloride | HCID 18975981 | — |
| Product | 4-amino-3,5-dichloro-N-{(1S)-1-[(cis)-octahydroisoquinolin-2(1H)-ylcarbonyl]-3-phenylpropyl}benzenesulfonamide | HCID 86659050 | — |
Reaction Steps
Example 115 is prepared from Boc-(L)-homophenylalanine, (±)-cis-decahydroisoquinoline, and 4-amino-3,5-dichlorobenzenesulfonyl chloride in the same manner that Example 1 is synthesized. ESI MS: Calc: 523.2; Found: 524.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859814B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-4ec079d8aa1442f8a0ddaee9a09a2461 |
| Source note | uspto-grants-2014_10 |