HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-D-homophenylalanine → 4-amino-3,5-dichloro-N-{(1R)-1-[(trans)-octahydroquinolin-1(2H)-ylcarbonyl]-3-phenylpropyl}benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-D-homophenylalanine | HCID 2755954 | — |
| Reactant | (4aS,8aR)-Decahydroquinoline | HCID 6994352 | — |
| Reactant | 4-Amino-3,5-dichlorobenzene-1-sulfonyl chloride | HCID 18975981 | — |
| Product | 4-amino-3,5-dichloro-N-{(1R)-1-[(trans)-octahydroquinolin-1(2H)-ylcarbonyl]-3-phenylpropyl}benzenesulfonamide | HCID 86659053 | — |
Reaction Steps
4-amino-3,5-dichloro-N-{(1R)-1-[(trans)-octahydroquinolin-1(2H) -ylcarbonyl]-3-phenylpropyl}benzenesulfonamide is prepared from Boc-(D)-homo -phenylalanine, (±)-trans-decahydroquinoline, and 4-amino-3,5dichlorobenzene -sulfonyl chloride in the same manner that Example 1 is synthesized. ESI MS: Calc: 523.2; Found: 524.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859814B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-9032c2f5cbf8477fbe8c7769a65c1844 |
| Source note | uspto-grants-2014_10 |