HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (R)-methyl 4-(1-(methylsulfonyloxy)butyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (R)-methyl 4-(1-hydroxybutyl)benzoate | HCID 68157820 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | (R)-methyl 4-(1-(methylsulfonyloxy)butyl)benzoate | HCID 86669087 | — |
Reaction Steps
To a solution of (R)-methyl 4-(1-hydroxybutyl)benzoate, intermediate (26) (10 g, 48 mmol) in methyl t-butyl ether (80 mL) containing triethylamine (6.32 g, 62 mmol) was added methanesulfonyl chloride (6.05 g, 53 mmol) slowly at 20° C. The solution was filtered to remove triethylamine salts and the solution used in the next step without isolation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859591B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-3b01d3b2fafe469caf250fc88749dd85 |
| Source note | uspto-grants-2014_10 |