HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 537525Generated: October 30, 2026
Water → (S)-methyl 4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoate
https://huagongshe.com/reaction/537525
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol | HCID 68157523 | — |
| Reactant | (R)-methyl 4-(1-(methylsulfonyloxy)butyl)benzoate | HCID 86669087 | — |
| Solvent | 2-Methyltetrahydrofuran | HCID 7301 | — |
| Product | (S)-methyl 4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoate | HCID 68156304 | — |
Reaction Steps
To a solution of 3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol (intermediate 26) (12.6 g, 49 mmol) in 2-methyltetrahydrofuran (70 mL) was added cesium carbonate (23.5 g, 72 mmol) and the solution of mesylate from step 2. The reaction was heated to 65° C. for 5 h. The reaction was then cooled to room temperature and water (80 mL) was added. The aq. layer was split and the organic solution was used in the next step without isolation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08859591B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-f739113e9e16431698a6ed2646ceccb0 |
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| Source note | uspto-grants-2014_10 |
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