2-Chloro-3-methyl-5-nitropyridine → 5-methyl-6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-amine

HRID 537536Notes

Reaction equation

HRID 537536 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][NH:6][CH:7]=1.Cl[C:11]1[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-])=O)=[CH:13][N:12]=1>>[CH3:17][C:16]1[CH:15]=[C:14]([NH2:18])[CH:13]=[N:12][C:11]=1[N:5]1[CH:4]=[C:3]([C:2]([F:9])([F:8])[F:1])[CH:7]=[N:6]1

Participants

3

Reactant 2

HCID 896482-Chloro-3-methyl-5-nitropyridineHCID 127777954-(Trifluoromethyl)-1H-pyrazole

Product 1

HCID 641737255-methyl-6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-amine

Procedure

The title compound was prepared by a method analogous to that described for Intermediate (6) using 4-trifluoromethyl-1H-pyrazole and 2-chloro-3-methyl-5-nitro-pyridine. 1H NMR (400 MHz, CDCl3, δ): 8.21 (s, 1H), 7.85 (s, 1H), 7.75 (d, J=2.4 Hz, 1H), 6.93 (d, J=2.4 Hz, 1H), 3.85 (s, 2H), 2.32 (s, 3H).

Sources & evidence

ORD record
ord-bd94f06c16084e9192d9a6bbf3d9c421
Source dataset
uspto-grants-2014_10
Patent number
US08859591B2

Reaction notes

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