Water → 6-Amino-5-chloro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione

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Reaction Steps

A mixture of 5-chloro-6-nitro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione (230 mg, 0.743 mmol), SnCl2.2 H2O (1.90 g, 7.43 mmol) and EtOH (300 mL) was refluxed for 24 h, then rota-evaporated to dryness. The residual solid was washed on a Bursch funnel with water (6×15 mL), and dried to give 153 mg (74%) of the title compound as a yellow powder. Mp >360° C. 1H NMR (DMSO-d6) 11.777 (s, IH), 11.360 (s, 1H), 7.140 (s, 1H), 5.499 (s, 2H).

Provenance & Evidence