HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 8-Amino-5-chloro-7-Trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 5-Chloro-8-nitro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione | HCID 10686343 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Amino-5-chloro-7-Trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione | HCID 10802656 | 93.9% |
Reaction Steps
A mixture of 5-chloro-8-nitro-7-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione (25 mg, 0.08 mmol), SnCl2.2 H2O (97 mg, 0.34 mmol) and EtOH (3 mL) was heated at 75° C. with stirring for 12 h. Work-up as above gave 21 mg (93%) of the title compound as a yellow powder. Mp >360° C. 1H NMR (DMSO-d6) 11.441 (s, 1H), 11.324 (s, 1H), 7.241 (s, 1H), 5.916 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620979 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-542fd133ebd1485cad318136f03f38a8 |
| Source note | uspto-grants-1997_04 |