4-Aminobiphenyl → HCID 58250037, compound

HRID 537656Notes

Reaction equation

HRID 537656 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1Br.[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:12][CH:11]=1>>[C:2]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:7]=[CH:6][C:5]([NH:9][C:10]2[C:11]([NH:9][C:10]3[CH:11]=[CH:12][C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)=[CH:14][CH:15]=3)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 71024-AminobiphenylHCID 114141,2-Dibromobenzene

Product 1

HCID 58250037HCID 58250037, compoundYield 80%

Procedure

The synthesis is carried out in accordance with the general procedure in accordance with Example 2 from 56.6 g (240 mmol) of 1,2-dibromobenzene and 85.4 g (505 mmol) of 4-aminobiphenyl. The precipitated solid is recrystallised from toluene/acetonitrile (5:1), and the residue is washed with MeOH, giving 78 g (189 mmol) of a crystalline solid. The overall yield is 80%.

Workup

  1. customThe precipitated solid is recrystallised from toluene/acetonitrile (5:1)
  2. washthe residue is washed with MeOH

Sources & evidence

ORD record
ord-8d3dba7f97234f6da4cec1c738e3ec37
Source dataset
uspto-grants-2014_10
Patent number
US08865321B2

Reaction notes

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