Methyl Methanesulfonate → Trimethoxysilylpropyltrimethylammonium methanesulfonate

Participants

Reaction Steps

5.0 g of trimethoxysilylpropyldimethylamine and 24 g of ethyl acetate were charged into a 100 mL flask to be dissolved. While stirring the resultant mixed solution with a magnetic stirrer, to the mixed solution, a solution in which 3.0 g of methyl methanesulfonate was dissolved in 26 g of ethanol was gradually added at room temperature in a nitrogen atmosphere. The reaction mixture was stirred for half a day and therefrom, ethanol was distilled off under reduced pressure. The resultant concentrate was dropped into 100 mL of diethyl ether and therefrom, trimethoxysilylpropyldimethylamine and methyl methanesulfonate as by-products were removed. This purification was repeated three times and then remaining diethyl ether was distilled off under reduced pressure, followed by dissolving the resultant concentrate in ethanol to obtain a 38.1% ethanol solution of trimethoxysilylpropyltrimethylammonium methanesulfonate.

Provenance & Evidence