HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57496385, compound → HCID 57496421, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57496385 | HCID 57496385 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 57496421 | HCID 57496421 | — |
Reaction Steps
Benzyl 2-cyclohexyl-4-phenylpiperidine-1-carboxylate (1.05 g, 2.78 mmol) in EtOH (50 ml) was added Pd/C (0.5 g, 0.235 mmol) and hydrogenated with a balloon overnight. Filtered through celite and concentrated. The trans isomer was removed on the chiral OD column 20% IPA/Hexanes w/DEA affording the single cis diastereomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865701B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-4310c8dc9c3a4f1682a3a0a664705109 |
| Source note | uspto-grants-2014_10 |