HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57496387, compound → HCID 57496388, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57496387 | HCID 57496387 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 57496388 | HCID 57496388 | 98.4% |
Reaction Steps
A suspension of 11 (500 mg, 1.2 mmol) and Pd(OH)2 (0.2 g) in 10 ml of EtOH was hydrogenated under 1 atmosphere of hydrogen at room temperature overnight. Filtration and concentration afforded (2S,4R)-2-(3,3-difluorocyclohexyl)-4-phenylpiperidine as a colorless oil (330 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865701B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-1db2a1904ed74bbbba8cb25ae8430ddd |
| Source note | uspto-grants-2014_10 |