Triethylamine → Phytanyl Mesylate

Participants

Reaction Conditions

Reaction Steps

To a solution of phytanol (14.98 g, 50.2 mmol) in anhydrous dichloromethane (150 mL) under nitrogen was added triethylamine (7.7 mL, 55.2 mmol). The solution was cooled to −10° C. and then a solution of methanesulfonyl chloride (11.51 g, 100.5 mmol) in anhydrous dichloromethane (100 mL) was added dropwise over 30 minutes. Upon completion, the solution was diluted to 500 mL using dichloromethane. The solution was washed twice with saturated NaHCO3, dried over MgSO4, filtered, and concentrated to dryness to afford the product as a colorless oil (18.9 g, 100%).

Provenance & Evidence