Dimethylamine → Benzyl 5-(dimethylamino)pentanoate

Participants

Reaction Steps

Benzyl 5-(methanesulfonyl)pentanoate (1.39 g, 4.85 mmol) was allowed to react in a 5.6M solution of dimethylamine in ethanol (100 mL) for 20 hours. The solution was then concentrated in vacuo to dryness. The resulting brown oil was purified by column chromatography (column 10″L×1″W; eluted with a gradient of 100% dichloromethane→2%/0.5%→4%/0.5% MeOH/NH4OH in dichloromethane) to afford the product as a yellow oil (0.79 g, 69%).

Provenance & Evidence