HCID 28826183, compound → HCID 28994099, compound

Participants

Reaction Steps

4-chloro-N-[3-(1H-imidazol-1-yl)propyl]-2-nitroaniline (11, 5 g, 17.8 mmol) was dissolved in 100 mL methanol (MeOH) and Palladium on activated carbon (10%, 120 mg, 0.1 eq.) was added under nitrogen atmosphere. The solution was hydrogenated at 1 bar for 16 hours. The reaction was filtered over celite and the filtrate concentrated in vacuo and purified by flash chromatography (gradient 0 to 10% methanol in CH2Cl2) to give 4-chloro-N1-[3-(1H-imidazol-1-yl)propyl]benzene-1,2-diamine (12, 2.18 g, 49%) as a solid; LCMS m/z=251 (M+H)+

Provenance & Evidence