HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 537855Generated: October 26, 2026
3-Aminophenol → tert-butyl 2-(2-((3-hydroxyphenyl)amino)oxazol-5-yl)-1H-indole-1-carboxylate
https://huagongshe.com/reaction/537855
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | tert-butyl 2-(2-chlorooxazol-5-yl)-1H-indole-1-carboxylate | HCID 71060197 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | tert-butyl 2-(2-((3-hydroxyphenyl)amino)oxazol-5-yl)-1H-indole-1-carboxylate | HCID 71060496 | — |
Reaction Steps
A mixture of tert-butyl 2-(2-chlorooxazol-5-yl)-1H-indole-1-carboxylate 21 (0.23 g, 0.723 mmol) and commercially available 3-aminophenol 8 (0.079 g, 0.724 mmol) in 2-propanol (20 mL) was heated to 80° C. for 14 h with stirring. Upon cooling, solvent was evaporated and silica column purified (Biotage) (Acetone/hexane as an eluent) to provide tert-butyl 2-(2-((3-hydroxyphenyl)amino)oxazol-5-yl)-1H-indole-1-carboxylate
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08865709B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-ca129ae308d84ed19f06ea23d49d9674 |
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| Source note | uspto-grants-2014_10 |
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