Sodium Hydroxide → HCID 59151226, compound

HRID 537892Notes

Reaction equation

HRID 537892 reaction equation
[OH-].[Na+].[NH:3]=[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[N:5]1[NH2:12].[C:13](OC)(=O)[CH2:14][OH:15]>C(O)C>[CH3:11][C:6]1[N:5]2[N:12]=[C:13]([CH2:14][OH:15])[N:3]=[C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 66774Methyl GlycolateHCID 59151224HCID 59151224, compound2×

Product 1

HCID 59151226HCID 59151226, compoundYield 10%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
55 °C

Procedure

To a solution of 0.79 g of sodium hydroxide in ethanol (20 mL) was added 2-imino-4,6-dimethyl-2H-pyridin-1-ylamine (1.7 g, 0.012 mol; obtained by HPLC purification of intermediate 10). After being stirred at 50-60° C. for 1 hour, methyl glycolate (1.4 g, 0.016 mol) was added, and the resulting mixture was stirred at reflux for 6 hours. After removal of the solvent under reduced pressure, the residue was purified by column chromatography on silica gel (ethyl acetate) to afford (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-methanol (0.2 g, 10%); 1H NMR (300 MHz, DMSO-d6): δ7.39 (s, 1H), 6.87 (s, 1H), 5.38 (t, J=6.3 Hz, 1H), 4.59 (d, J=6.3 Hz, 2H), 2.64 (s, 3H), 2.38 (s, 3H). A mixture of this compound (31 mg, 0.175 mmol) and SOCl2 (10 mL) in dry CH2Cl2 (10 mL) was stirred at room temperature for 2 hours. The solvent and excess SOCl2 was evaporated under vacuum to yield the title compound as a crude product, which was used for the preparation of final compounds without purification or characterization.

Workup

  1. stirringthe resulting mixture was stirred
  2. temperatureat reflux for 6 hours
  3. customAfter removal of the solvent under reduced pressure
  4. customthe residue was purified by column chromatography on silica gel (ethyl acetate)

Sources & evidence

ORD record
ord-0724ef8ce9f0427686b8c0f6596fe329
Source dataset
uspto-grants-2014_10
Patent number
US08865711B2

Reaction notes

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