HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 4-(Pyrrolidin-1-yl)furan-2(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | (+-)-3-Methyl-2,4(3H,5H)-furandione | HCID 544553 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(Pyrrolidin-1-yl)furan-2(5H)-one | HCID 13402454 | — |
Reaction Steps
A mixture of methyl tetronate (2.0 g, 17.5 mmol) and pyrrolidine (4.0 mL, 48 mmol) in EtOH (20 mL) was heated at reflux for 2 hours. The mixture was cooled to room temperature, and evaporated to dryness. The resulting solid was recrystallized with benzene/hexanes to give 4-pyrrolidin-1-ylfuran-2(5H)-one as white crystals. Yield: 2.60 g, 96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865682B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-0735f2bac6eb4446b2c354722ed76214 |
| Source note | uspto-grants-2014_10 |