Sodium Azide → HCID 86693822, compound

Participants

Reaction Steps

3.4 1.50 g (23.1 mmol) of sodium azide are added to a solution of 2.00 g (7.43 mmol) of 3-azetidin-1-yl-1-phenylpropyl methanesulfonate in 50 ml of DMF, and the mixture is stirred at room temperature for 48 hours. The reaction mixture is partitioned between water and ethyl acetate. The organic phase is dried over sodium sulfate, evaporated, and the residue is chromatographed on a silica-gel column with ethyl acetate/methanol as eluent: 1-(3-azido-3-phenylpropyl)azetidine as colourless viscous oil; HPLC/MS 0.9 min; [M+H] 217.

Provenance & Evidence