反应详情

To a suspension of tetrahydro-2-furoic acid (38 mg, 0.32 mmol) in DCM (3 mL) 1,1-carbonyldiimidazole (52 mg, 0.32 mmol) was added and the mixture was stirred for 6 hours at room temperature. Then 3-[trans-4-(piperazine-1-carbonyl)-cyclohexylmethyl]-1H-quinazoline-2,4-dione (100 mg, 0.27 mmol) was added and the reaction left stirring for 18 hours. The mixture was washed with 0.4 M Na2CO3 solution and the organic phase collected and concentrated under reduced pressure. The crude was purified by silica column eluting with DCM:MeOH (98:2). 70 mg of the titled compound were obtained (yield 55%).

1. additionwas added
2. waitthe reaction left
3. stirringstirring for 18 hours
4. washThe mixture was washed with 0.4 M Na2CO3 solution
5. customthe organic phase collected
6. concentrationconcentrated under reduced pressure
7. customThe crude was purified by silica column
8. washeluting with DCM:MeOH (98:2)