Diethyl Ether → HCID 178454418, compound

Participants

Reaction Steps

A solution of 3-amino-N-[trans-4-(4-isobutyryl-piperazine-1-carbonyl)-cyclohexylmethyl]-3-phenyl-propionamide (0.13 g, 0.29 mmol) and 1,1-carbonyldiimidazole (0.10 g, 0.58 mmol) in CH3CN was irradiated with microwave at 100° C. (250 watt) for 10 minutes. The solvent was removed under reduced pressure and the residue was washed with H2O and then with diethylether, affording 31 mg of the titled compound (22% yield).

Provenance & Evidence