HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 178481612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 178481613 | HCID 178481613 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178481612 | HCID 178481612 | 27% |
Reaction Steps
trans-4-(3-Methyl-2-oxo-6-trifluoromethyl-2,3-dihydro-benzoimidazol-1-ylmethyl)cyclohexanecarboxylic acid (78 mg, 0.22 mmol), HATU (100 mg, 0.26 mmol), morpholine (23 mg, 0.26 mmol) and triethyl amine (0.04 ml, 0.26 mmol) were dissolved in DMSO and the mixture were shaken overnight. 3 ml of a saturated solution of ammonium chloride and 2 ml of DCM were added and the organic layer was separated and washed with water. The organic solvent was evaporated and the crude was purified by silica column using ethyl acetate as eluent. 25 mg (yield 27%) of the titled compound were isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865704B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-bdc7b1a0597d4ed792a9ba8a01fbadd4 |
| Source note | uspto-grants-2014_10 |