HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178418361, compound → HCID 178501128, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Reactant | HCID 178501129 | HCID 178501129 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178501128 | HCID 178501128 | 100% |
Reaction Steps
A solution of trans-4-{[2-(2-Nitro-phenyl)-acetylamino]-methyl}-cyclohexanecarboxylic acid methyl ester (4 g) in MeOH (600 mL) was submitted to continuous flow rate hydrogenation by H-Cube (ThalesNano®) using a 10% Pd/C cartridge (small cartridge, full hydrogen mode, flux 0.6 ml/min, P=1 atm). Finally, the solvent was removed under reduced pressure to obtain the titled compound (3.64 g, quantitative yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865704B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-75a0f8d4fcc84c538494670a11981620 |
| Source note | uspto-grants-2014_10 |