Acetic Acid → HCID 178501121, compound

Participants

Reaction Steps

A solution 0.01 M of trans-4-{[2-(2-Nitro-phenyl)-ethylamino]-methyl}-cyclohexanecarboxylic acid methyl ester (2 g, 6.25 mmol) in MeOH (625 mL) with ˜1% of glacial AcOH (6.25 mL) was submitted to continuous flow rate hydrogenation by H-Cube (ThalesNano®) using a 10% Pd/C cartridge (small type cartridge, full hydrogen mode, flowrate of 1 mL/min). Finally, the solvent was removed under reduced pressure to obtain the titles compound (3.07 g, quantitative yield).

Provenance & Evidence