反应详情

A solution of 2-bromo-1,4-dichlorobenzene (1.000 g, 4.443 mmol, Aldrich, used as received) in fuming HNO3 (7.0 mL) was stirred at 50° C. for 1.5 h and poured into ice (80 g). The yellowish precipitate was filtered, washed with water (10 mL) and dried under vacuum to give 1.14 g (95%) of pure title compound as a yellowish powder; m.p. 50°-53° C.; 1H NMR (CDCl3): 7.863 (s, 1H), 8.030 (s, 1H).

1. filtrationThe yellowish precipitate was filtered
2. washwashed with water (10 mL)
3. customdried under vacuum