反应详情

温度

60 °C

A mixture of 1-bromo-2,5-difluoro-4-nitro-benzene (1.50 g, 6.30 mmol) and 7M ammonia in methanol (25 mL) was heated in a sealed tube at 60° C. for 15 h. The reaction mixture was transferred to a round bottom flask, washing the sealed tube with EtOAc. The reaction mixture was concentrated, and the crude material was used in the next step without further purification.

1. customThe reaction mixture was transferred to a round bottom flask
2. washwashing the sealed tube with EtOAc
3. concentrationThe reaction mixture was concentrated
4. customthe crude material was used in the next step without further purification