5-Chloro-2-nitro-4-(trifluoromethoxy)aniline → 4-Chloro-5-(trifluoromethoxy)-1,2-benzenediamine

Participants

Reaction Steps

5-Chloro-2-nitro-4-trifluoromethoxy-phenylamine (180 g, 0.7 mol, 1.0 equiv.) was dissolved in dry DMF (1 L) and then 5% Pt/C containing 50.2% water (4.0 g) was added. The reaction solution was hydrogenated (50 psi) at room temperature for 16 hours. HPLC analysis indicated complete reaction. MS [M+H]+ found 225.2. The reaction solution was used on the next step without isolation.

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