反应详情

温度

100 °C

A solution of (2,6-dibromo-4-fluoro-phenyl)-thiourea (0.300 g, 0.920 mmol) and 1M aq. KOH (7.23 mL) was heated to 100° C. Lead (II) acetate trihydrate (0.400 g, 1.05 mmol) in water (2 mL) was then added. The mixture was heated at 100° C. for another 10 minutes while a precipitate was observed. The mixture was cooled to 0° C. and filtered to provide a clear colorless solution. The filtrate was acidified to pH 5 with acetic acid. The precipitate was collected by filtration to yield titled compound (0.170 g, 63%). 1H NMR (400 MHz, DMSO-d6): 7.80-7.78 (m, 2H).

1. temperatureThe mixture was cooled to 0° C.
2. filtrationfiltered
3. customto provide a clear colorless solution
4. filtrationThe precipitate was collected by filtration