Methyl iodide → 1-Methylcytosine

HRID 538232Notes

Reaction equation

HRID 538232 reaction equation
N1C=CC(N)=NC1=O.CI.[NH2:11][C:12]1[CH:17]=[CH:16][N:15]([CH2:18]C2C=CC=CC=2)[C:14](=[O:25])[N:13]=1>>[NH2:11][C:12]1[CH:17]=[CH:16][N:15]([CH3:18])[C:14](=[O:25])[N:13]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 3085814-Amino-1-benzylpyrimidin-2(1H)-oneHCID 178418229Cytosine

Product 1

HCID 791431-Methylcytosine

Procedure

4-Amino-1-methyl-1H-pyrimidin-2-one was prepared from cytosine and methyliodide using the methods described above for the preparation of 4-amino-1-benzyl-1H-pyrimidin-2-one.

Sources & evidence

ORD record
ord-0087f7e1c56f48e785f663757a860771
Source dataset
uspto-grants-2014_10
Patent number
US08865725B2

Reaction notes

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