1,3-Dichloroacetone → 2-Chloromethyl-6-methyl-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538235Notes

Reaction equation

NC1C=CN(C)C(=O)N=1.ClCC(CCl)=O.[Cl:16][CH2:17][C:18]1[N:19]=[C:20]2[CH:25]=[CH:24][N:23]([C:26]3C=CC(F)=CC=3)[C:22](=[O:33])[N:21]2[CH:34]=1>>[Cl:16][CH2:17][C:18]1[N:19]=[C:20]2[CH:25]=[CH:24][N:23]([CH3:26])[C:22](=[O:33])[N:21]2[CH:34]=1

Participants

Reactant 3

HCID 107931,3-Dichloroacetone

HCID 791431-Methylcytosine

HCID 682908442-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

Product 1

HCID 682903772-Chloromethyl-6-methyl-6H-imidazo[1,2-c]pyrimidin-5-one

Procedure

2-Chloromethyl-6-methyl-6H-imidazo[1,2-c]pyrimidin-5-one was prepared from 4-amino-1-methyl-1H-pyrimidin-2-one and 1,3-dichloroacetone using the methods described above for the preparation of 2-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one.

Sources & evidence

ORD record: ord-cc131df0b8014e1d9ea2ee3c4c3fa14d
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08865725B2

Reaction notes

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