1,3-Dichloroacetone → 2-Chloromethyl-6-cyclopropylmethyl-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538236Notes

Reaction equation

NC1C=CN(CC2CC2)C(=O)N=1.ClCC(CCl)=O.[Cl:19][CH2:20][C:21]1[N:22]=[C:23]2[CH:28]=[CH:27][N:26]([C:29]3[CH:34]=[CH:33][C:32](F)=CC=3)[C:25](=[O:36])[N:24]2[CH:37]=1>>[Cl:19][CH2:20][C:21]1[N:22]=[C:23]2[CH:28]=[CH:27][N:26]([CH2:29][CH:34]3[CH2:33][CH2:32]3)[C:25](=[O:36])[N:24]2[CH:37]=1

Participants

Reactant 3

HCID 107931,3-Dichloroacetone

HCID 214443201-Cyclopropylmethylcytosine

HCID 682908442-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

Product 1

HCID 682906012-Chloromethyl-6-cyclopropylmethyl-6H-imidazo[1,2-c]pyrimidin-5-one

Procedure

2-Chloromethyl-6-cyclopropylmethyl-6H-imidazo[1,2-c]pyrimidin-5-one was prepared from 4-amino-1-cyclopropylmethyl-1H-pyrimidin-2-one and 1,3-dichloroacetone using the methods described above for the preparation of 2-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one.

Sources & evidence

ORD record: ord-16e8acce3ba246edbda2175d886d0296
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08865725B2

Reaction notes

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