HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → 5-[((1-Decylsulfonyl)amino)carbonyl]3-methoxypyridine-2-carboxylic acid N-(((1-butyloxy)carbonyl)methyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Glycine | HCID 750 | — |
| Reactant | 5-[((1-Decylsulfonyl)amino)carbonyl]-3-methoxypyridine-2-carboxylic acid | HCID 19960357 | — |
| Reactant | HCID 22363161 | HCID 22363161 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-[((1-Decylsulfonyl)amino)carbonyl]3-methoxypyridine-2-carboxylic acid N-(((1-butyloxy)carbonyl)methyl)amide | HCID 54156002 | — |
Reaction Steps
The title compound was prepared from 0.5 g (1.25 mmol) of 5-[((1-decylsulfonyl)amino)carbonyl]-3-methoxypyridine-2-carboxylic acid (cf. Example 25a)) and 0.46 g (1.5 mmol) of glycine 1-butyl ester tosylate (prepared from glycine, 1-butanol, p-tos.OH using toluene in a water separator). 0.31 g of product was obtained, m.p. 82°-85° C. (from diisopropyl ether/ethyl acetate (2:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620996 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-7a4a5f16bcc6411c93a5350677c56738 |
| Source note | uspto-grants-1997_04 |