HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 67606185, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate | HCID 8027233 | — |
| Reactant | tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate | HCID 16228674 | — |
| Product | HCID 67606185 | HCID 67606185 | 75% |
Reaction Steps
The procedure described in Example 3, step 3.4. is followed. Starting from 3.00 g (15.13 mmol) of tert-butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate, 2.58 g (15.13 mmol) of ethyl 5-hydroxymethyl-isoxazole-3-carboxylate, 5.27 ml (30.26 mmol) of N,N-diisopropylethylamine and 3.05 g (15.13 mmol) of para-nitrophenyl chloroformate, 4.50 g of product are obtained in the form of a colourless oil (75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865738B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-d26d947d94274b559111b4ce660c0812 |
| Source note | uspto-grants-2014_10 |