反应详情

A solution of imidazole from step 4 above (550 mg, 1.6 mmol) in methanol (10 ml) was stirred at 25° C. while a solution of OXONE® (1.6 g) in water (3 ml) was added. The reaction mixture was stirred for 3 hours at room temperature, poured into water (50 ml) and extracted with methylene chloride. After drying the organic layer (Na2SO4) and concentration, the residue was treated with cold ethyl acetate, filtered, and air dried to give 490 mg (80%) of the titled material which was identical with Examples 1 Method A and Method B.

1. additionwas added
2. extractionextracted with methylene chloride
3. customAfter drying
4. concentrationthe organic layer (Na2SO4) and concentration
5. additionthe residue was treated with cold ethyl acetate
6. filtrationfiltered
7. customair dried