反应详情

To a solution of 5-(2-(4-fluorophenyl)oxazol-4-yl)-3-methoxypyridin-2-amine (145 mg, 0.5 mmol) in chloroform (20 mL) at 0° C. was added a pre-cooled solution of bromine (40 μL, 0.7 mmol) in CHCl3 (5 mL). The reaction mixture was stirred for <5 min, concentrated in vacuo, and the resulting residue was azeotroped with CHCl3 (2×). Purification by flash chromatography (SiO2, 100:0-95:5 DCM-MeOH) provided 135 mg of 5-(5-bromo-2-(4-fluorophenyl)oxazol-4-yl)-3-methoxypyridin-2-amine as a yellow solid: LCMS (m/z): 365.8 (MH+), tR=0.83 min.

1. concentrationconcentrated in vacuo
2. customthe resulting residue was azeotroped with CHCl3 (2×)
3. customPurification by flash chromatography (SiO2, 100:0-95:5 DCM-MeOH)