Bismuth-oxygen → 1-(3-Fluoro-4-methoxyphenyl)-2-[4-(methylthio)phenyl]ethane-1,2-dione

Participants

Reaction Conditions

Reaction Steps

1-(3-Fluoro-4-methoxyphenyl)-2-hydroxy-2-[4-(methylthio)phenyl]ethanone from step 2 (6.5 mmol, 2.00 g) was diluted with glacial acetic acid (30 mL). Bismuth oxide (11.4 mmol, 5.30 g) was added and the mixture was heated at 90° C. for 2 hours. The crude mixture was filtered through Celite® filter agent, lyophilized and subjected to chromatography, affording the title compound as a yellow solid (642 mg, 32%).

Provenance & Evidence