Acetonitrile → 6-Chloro-2-fluoro-3-methoxybenzamide

HRID 538502Notes

Reaction equation

HRID 538502 reaction equation
[Cl:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([F:11])[C:5]([O:12][CH3:13])=[CH:4][CH:3]=1.CC#[N:16]>>[Cl:1][C:2]1[C:7]([C:8]([NH2:16])=[O:9])=[C:6]([F:11])[C:5]([O:12][CH3:13])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 38560396-Chloro-2-fluoro-3-methoxybenzoic acid

Product 1

HCID 179993606-Chloro-2-fluoro-3-methoxybenzamideYield 85%

Procedure

Synthesised from commercially available 6-chloro-2-fluoro-3-methoxybenzenecarboxylic acid according to Method A, scheme 1. Yield 85%, mp 154-156° C., HPLC-MS (method 1): m/z 245 [M+H+CH3CN]+, Rt=2.37 min.

Sources & evidence

ORD record
ord-d5d47ec97fd44b06be72527669574633
Source dataset
uspto-grants-2014_10
Patent number
US08865736B2

Reaction notes

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