[5-(Trifluoromethyl)-1-benzothiophen-2-yl]methanol → 2,6-Difluoro-3-[5-(trifluoromethyl)-1-benzothiophen-2-yl]methoxybenzenecarboxamide

HRID 538537Notes

Reaction equation

HRID 538537 reaction equation
[F:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10]([NH2:12])=[O:11].[F:13][C:14]([F:27])([F:26])[C:15]1[CH:16]=[CH:17][C:18]2[S:22][C:21]([CH2:23]O)=[CH:20][C:19]=2[CH:25]=1>>[F:1][C:2]1[C:7]([O:8][CH2:23][C:21]2[S:22][C:18]3[CH:17]=[CH:16][C:15]([C:14]([F:26])([F:13])[F:27])=[CH:25][C:19]=3[CH:20]=2)=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10]([NH2:12])=[O:11]

Participants

3

Reactant 2

HCID 36995549[5-(Trifluoromethyl)-1-benzothiophen-2-yl]methanolHCID 451201362,6-Difluoro-3-hydroxybenzamide

Product 1

HCID 594027122,6-Difluoro-3-[5-(trifluoromethyl)-1-benzothiophen-2-yl]methoxybenzenecarboxamideYield 3%

Procedure

Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide and [5-(trifluoromethyl)-1-benzothiophen-2-yl]methanol according to Method C, scheme 3. Yield 3%, mp 150-152° C., HPLC-MS (method 1): m/z 386 [M−H]−, Rt=4.39 min.

Sources & evidence

ORD record
ord-38e0cda07b444386bcdbb0b7f7f439bc
Source dataset
uspto-grants-2014_10
Patent number
US08865736B2

Reaction notes

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