6-Chloro-2-benzothiazolamine → 3-[(6-Chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboxamide

HRID 538543Notes

Reaction equation

HRID 538543 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7](N)[S:8][C:4]=2[CH:3]=1.C([CH2:14][O:15][C:16]1[C:17]([F:26])=[C:18]([C:23]([NH2:25])=[O:24])[C:19]([F:22])=[CH:20][CH:21]=1)#N>>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([CH2:14][O:15][C:16]3[C:17]([F:26])=[C:18]([C:23]([NH2:25])=[O:24])[C:19]([F:22])=[CH:20][CH:21]=3)[S:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 72266-Chloro-2-benzothiazolamineHCID 594028043-(Cyanomethoxy)-2,6-difluorobenzenecarboxamide

Product 1

HCID 462371393-[(6-Chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzenecarboxamideYield 38%

Procedure

Synthesised from 6-chloro-1,3-benzothiazol-2-amine and 3-(cyanomethoxy)-2,6-difluorobenzene carboxamide, according to Method K, scheme 26. Yield 38% (second step), mp 190-191° C., HPLC-MS (method 1): m/z 355 [M+H]+, Rt=3.85 min.

Sources & evidence

ORD record
ord-e7d52f69ef5441edaa707db12469e034
Source dataset
uspto-grants-2014_10
Patent number
US08865736B2

Reaction notes

Loading…