HuagongsheHuagongshe Chemistry Print Report · For research reference only
Riluzole → 2,6-Difluoro-3-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]methoxybenzenecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Riluzole | HCID 5070 | — |
| Reactant | 3-(Cyanomethoxy)-2,6-difluorobenzenecarboxamide | HCID 59402804 | — |
| Product | 2,6-Difluoro-3-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]methoxybenzenecarboxamide | HCID 59403008 | 34% |
Reaction Steps
Synthesised from 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine and 3-(cyanomethoxy)-2,6-difluorobenzenecarboxamide, according to Method K, scheme 26. Yield 34% (second step), mp 174-175° C., HPLC-MS (method 1): m/z 405 [M+H]+, Rt=4.14 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865736B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-b999d832cf2249bc8cb3d80176f7ab7b |
| Source note | uspto-grants-2014_10 |