Hydrochloric Acid → HCID 66620348, compound

Participants

Reaction Steps

tert-Butyl N-[4-(5-[3-(aminocarbonyl)-2,4-difluorophenoxy]methyl-1,2,4-oxadiazol-3-yl)phenyl]carbamate (300 mg, 0.67 mmol, 1 equiv.) was dissolved in 4N HCl in dioxane (7 ml, 28 mmol, 42 equiv.) and the reaction mixture was stirred at r.t. overnight. Volatiles were removed under reduced pressure, the residue was triturated with dry Et2O and the solid formed was filtered and rinsed with dry Et2O. The crude product (200 mg) was taken-up in EtOH (2 ml) and was triturated with 2N HCl in Et2O solution (0.3 ml) and dry Et2O. The white solid was filtered and washed with dry Et2O, to give 110 mg of the desired product (43% yield). HPLC-MS (method 1): m/z 347 [M+H-HCl]+, Rt=2.98 min.

Provenance & Evidence