反应详情

To 180 mg (0.53 mmol) of (S)-1-(tetrahydro-pyran-4-yl)-pyrrolidine-2-carboxylic acid [3-(2-hydroxy-1,1-dimethyl-ethyl)-isoxazol-5-yl]-amide in DCM (1.74 mL) are added 317 mg (0.75 mmol) of (1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one (Dess-Martin-periodinane). The reaction mixture is stirred at RT for 1 h, diluted with sat. aq. NaHCO3 solution and stirred for additonal 30 min. The layers are separated; the organic layer is washed with brine and dried over Na2SO4. The solvent is removed under reduced pressure, the residue is purified by silica gel chromatographie (eluent: EE) to afford 93.0 mg of (S)-1-(tetrahydro-pyran-4-yl)-pyrrolidine-2-carboxylic acid [3-(1,1-dimethyl-2-oxo-ethyl)-isoxazol-5-yl]amide. Yield: 52%; ESI-MS: 336 [M+H]+; HPLC (Rt): 1.12 min (method E)

1. stirringstirred for additonal 30 min
2. customThe layers are separated
3. washthe organic layer is washed with brine
4. dry with materialdried over Na2SO4
5. customThe solvent is removed under reduced pressure
6. customthe residue is purified by silica gel chromatographie (eluent: EE)