1,1,1-Trifluoro-2-iodoethane → HCID 25116069, compound

HRID 538701Notes

Reaction equation

HRID 538701 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:10]2[C:14]([CH3:16])([CH3:15])[C:13](=[O:17])[N:12]([CH:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:33])[CH2:25][N:26]4[C:30](=[O:31])[CH2:29][CH2:28][C:27]4=[O:32])[CH2:20][CH2:19]3)[N:11]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[F:34][C:35]([F:39])([F:38])[CH2:36]I>>[CH3:9][O:8][C:7]1[CH:6]=[CH:5][C:4]([C:10]2[C:14]([CH3:15])([CH3:16])[C:13](=[O:17])[N:12]([CH:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:33])[CH2:25][N:26]4[C:27](=[O:32])[CH2:28][CH2:29][C:30]4=[O:31])[CH2:20][CH2:19]3)[N:11]=2)=[CH:3][C:2]=1[O:1][CH2:36][C:35]([F:39])([F:38])[F:34]

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 66616564HCID 66616564, compound2×

Product 1

HCID 25116069HCID 25116069, compound

Procedure

Prepared analogously as described for example 5 using 1-(2-{4-[3-(3-hydroxy-4-methoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione (compound A4) and 1,1,1-trifluoro-2-iodoethane as starting compounds.

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-f08c65117b8b4c13b1086c66b180da76
Source dataset
uspto-grants-2014_10
Patent number
US08865745B2

Reaction notes

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