Methyl isobutyrate → Methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate

HRID 538721Notes

Reaction equation

[CH3:1][CH:2]([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[CH:8]1([CH2:11][O:12][C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=2[O:22][CH:23]([F:25])[F:24])[C:16](Cl)=[O:17])[CH2:10][CH2:9]1>>[CH:8]1([CH2:11][O:12][C:13]2[CH:14]=[C:15]([C:16](=[O:17])[C:2]([CH3:7])([CH3:1])[C:3]([O:5][CH3:6])=[O:4])[CH:19]=[CH:20][C:21]=2[O:22][CH:23]([F:25])[F:24])[CH2:10][CH2:9]1

Participants

Reactant 2

HCID 11039Methyl isobutyrate

HCID 120473303-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride

Product 1

HCID 66616523Methyl 3-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2,2-dimethyl-3-oxopropanoate

Procedure

Prepared analogously as described for example D1 using methyl 2-methylproponate and 3-cyclopropylmethoxy-4-difluoromethoxybenzoyl chloride as starting compounds.

Workup

customPrepared analogously

Sources & evidence

ORD record: ord-2dad4a6073644e4c9188dd2f092f5cb2
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08865745B2

Reaction notes

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