HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → HCID 66851591, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 3,3-Dimethylbutanal | HCID 76335 | — |
| Reactant | 2-Propanol, 1-amino-2-methyl- | HCID 95102 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 66851591 | HCID 66851591 | 94.6% |
Reaction Steps
A mixture of 3,3-dimethylbutanal (7.7 mL, 62 mmol), 1-amino-2-methylpropan-2-ol (5.0 g, 56 mmol), 4 Å molecular sieves (5 g, 8-12 mesh beads), potassium thiocyanate (7.3 g, 75 mmol) and iodine (14 g, 56 mmol) in acetonitrile (100 mL) were processed as described in Example 18A to provide the title compound (12 g, 53 mmol, 94% yield). MS (DCI/NH3) m/z 229 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-87aec084992547268fd53cca564d3a88 |
| Source note | uspto-grants-2014_10 |