HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 1-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclopropanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | 3,3-Dimethylbutanal | HCID 76335 | — |
| Reactant | Potassium thiocyanate | HCID 516872 | — |
| Reactant | 1-(Aminomethyl)cyclopropan-1-ol | HCID 12609623 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclopropanol | HCID 66851925 | 95.7% |
Reaction Steps
A mixture of 1-(aminomethyl)cyclopropanol (ChemPacific, 1.0 g, 11.5 mmol), 3,3-dimethylbutanal (1.6 mL, 12.6 mmol), 4 Å molecular sieves (3 g, 8-12 mesh beads), potassium thiocyanate (1.5 g, 15 mmol) and iodine (2.9 g, 11.5 mmol) in acetonitrile (25 mL) were processed as described in Example 18A to provide the title compound (2.5 g, 11 mmol, 95% yield). MS (DCI/NH3) m/z 227 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08865753B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-69a917923d6e44ed966992dd566e2edc |
| Source note | uspto-grants-2014_10 |