Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 5-Tert-butyl-3-(cyclobutylmethyl)thiazol-2(3h)-imine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 5-tert-Butyl-1,3-thiazol-2-amine | HCID 676485 | — |
| 반응물 | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| 생성물 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | 5-Tert-butyl-3-(cyclobutylmethyl)thiazol-2(3h)-imine | HCID 66851503 | 80% |
반응 단계
A mixture of Example 74A (1.56 g, 10 mmol) and (bromomethyl)cyclobutane (1.1 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 18 h. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% MeOH in EtOAc then 9:1:0.1 CH2Cl2:MeOH:NH4OH) to provide the title compound (1.8 g, 80% yield). MS, DCI, m/z 225 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08865753B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-39c4fcbe98324ca180ef23a4018b1d71 |
| 출처 메모 | uspto-grants-2014_10 |