HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 538795Generated: October 27, 2026
4-Bromo-1,1,1-trifluorobutane → 5-tert-butyl-3-(4,4,4-trifluorobutyl)thiazol-2(3H)-imine hydrobromide
https://huagongshe.com/reaction/538795
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromo-1,1,1-trifluorobutane | HCID 521006 | — |
| Reactant | 5-tert-Butyl-1,3-thiazol-2-amine | HCID 676485 | — |
| Product | 5-tert-butyl-3-(4,4,4-trifluorobutyl)thiazol-2(3H)-imine hydrobromide | HCID 66852123 | 63% |
Reaction Steps
A mixture of the product of Example 74A (0.25 g, 1.6 mmol) and 1-bromo-4,4,4-trifluorobutane (336 mg, 1.8 mmol) was warmed to 85° C. and was stirred for 16 hours. The mixture was cooled to ambient temperature and the title compound (0.35 g, 63% yield) was isolated via filtration. MS (DCI/NH3) m/z 267 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08865753B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-0dc99587664e418aa026073806f002c1 |
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| Source note | uspto-grants-2014_10 |
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