Thionyl Chloride → HCID 75058251, compound
Reaction equation
[C:1]12([C:11]([OH:13])=O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[O:2]1)[CH2:8]2.S(Cl)([Cl:16])=O>>[C:1]12([C:11]([Cl:16])=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[O:2]1)[CH2:8]2Participants
3
Procedure
A solution of Example 81B (0.1 g, 0.55 mmol) in 5 mL of thionyl chloride was warmed to reflux and stirred for 2 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The residue was diluted with 5 mL of toluene and concentrated under reduced pressure three times to afford the title compound, which was used without additional purification or characterization.
Workup
- temperatureto reflux
- concentrationconcentrated under reduced pressure
- additionThe residue was diluted with 5 mL of toluene
- concentrationconcentrated under reduced pressure three times
Sources & evidence
- ORD record
- ord-ad8e1afd0af04c93988a88aec06ccaa5
- Source dataset
- uspto-grants-2014_10
- Patent number
- US08865753B2
Reaction notes
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