Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | HCID 66852048 | HCID 66852048 | 80% |
Reaction Steps
A mixture of 2-aminothiazole (1.0 g, 10 mmol) and (bromomethyl)cyclobutane (1.1 mL, 10 mmol) was warmed to 85° C. and was allowed to stir for 18 h. The mixture was cooled to ambient temperature and the crude material was purified via column chromatography (SiO2, 10% MeOH in EtOAc then 9:1:0.1 CH2Cl2:MeOH:NH4OH) to provide the title compound (1.4 g, 8.0 mmol, 80% yield). MS (DCI/NH3) m/z 169 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08865753B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-9f115477a55c4c2e81f8f5400a176ae8 |
|---|
| Source note | uspto-grants-2014_10 |
|---|
